SCOPe 2.07: Domain d3wymb_: 3wym B:

Lineage for d3wymb_ (3wym B:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.0: automated matches [191566] (1 protein)
   not a true family

6. Protein automated matches [190983] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188676] (136 PDB entries)

8. Domain d3wymb_: 3wym B: [261192]
   automated match to d4lm1a_
   complexed with 3k9, mg, zn

Details for d3wymb_

PDB Entry: 3wym, 2 Å

PDB Description: crystal structure of the catalytic domain of pde10a complexed with 1- (2-fluoro-4-(1h-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1h- pyrazol-5-yl)pyridazin-4(1h)-one

PDB Compounds: (B:) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

SCOPe Domain Sequences for d3wymb_:

Sequence; same for both SEQRES and ATOM records:

>d3wymb_ a.211.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfims
vkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsy
lqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatd
lalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiya
efwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllka
crdnlsqwekvirge

Timeline for d3wymb_:

• d3wymb_ first appeared in SCOPe 2.04
  
• d3wymb_ appears in SCOPe 2.06
  
• d3wymb_ appears in the current release, SCOPe 2.08