SCOPe 2.06: Domain d3wmha_: 3wmh A:

Lineage for d3wmha_ (3wmh A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (113 PDB entries)
   Uniprot P37231 232-505

8. Domain d3wmha_: 3wmh A: [261181]
   automated match to d3tkma_
   complexed with jja

Details for d3wmha_

PDB Entry: 3wmh, 2.1 Å

PDB Description: human ppar gamma ligand binding domain in complex with a gammma selective synthetic partial agonist mekt75

PDB Compounds: (A:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d3wmha_:

Sequence, based on SEQRES records:

>d3wmha_ a.123.1.1 (A:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
npesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikf
khitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvhe
iiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdl
aifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrq
ivtehvqllqvikktetdmslhpllqeiykdl

Sequence, based on observed residues (ATOM records):

>d3wmha_ a.123.1.1 (A:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
npesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikf
khkevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlas
lmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiavii
lsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvql
lqvikktetdmslhpllqeiykdl

Timeline for d3wmha_:

• d3wmha_ first appeared in SCOPe 2.04
  
• d3wmha_ appears in SCOPe 2.05
  
• d3wmha_ appears in SCOPe 2.07
  
• d3wmha_ appears in the current release, SCOPe 2.08