SCOP 1.75: Domain d1de7.2: 1de7 J:,K:

Lineage for d1de7.2 (1de7 J:,K:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (164 PDB entries)
   Uniprot P00734 331-361,364-421
   Uniprot P00734 334-360 364-510 518-619
   Uniprot P00734 328-620
   Uniprot P00734 355-621
   Uniprot P00734 328-620
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1de7.2: 1de7 J:,K: [26096]
   complexed with ch2, na

Details for d1de7.2

PDB Entry: 1de7, 2 Å

PDB Description: interaction of factor xiii activation peptide with alpha-thrombin: crystal structure of the enzyme-substrate complex

PDB Compounds: (J:) alpha-thrombin (light chain), (K:) alpha-thrombin (heavy chain)

SCOP Domain Sequences for d1de7.2:

Sequence, based on SEQRES records:

>g1de7.2 b.47.1.2 (J:,K:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanvg
kgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmks
pfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfg

Sequence, based on observed residues (ATOM records):

>g1de7.2 b.47.1.2 (J:,K:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketgqpsvl
qvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwy
qmgivswgegcdrdgkygfythvfrlkkwiqkvidqfg

Timeline for d1de7.2:

• d1de7.2 first appeared (with stable ids) in SCOP 1.55
  
• d1de7.2 appears in SCOP 1.73
  
• d1de7.2 appears in SCOPe 2.01
  
• d1de7.2 appears in the current release, SCOPe 2.08