SCOPe 2.04: Domain d4p38b_: 4p38 B:

Lineage for d4p38b_ (4p38 B:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein automated matches [190085] (43 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186828] (10 PDB entries)

8. Domain d4p38b_: 4p38 B: [260937]
   automated match to d4bb6a_
   complexed with 21t, cl, ndp

Details for d4p38b_

PDB Entry: 4p38, 2.8 Å

PDB Description: human 11beta-hydroxysteroid dehydrogenase type 1 in complex with azd8329

PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d4p38b_:

Sequence, based on SEQRES records:

>d4p38b_ c.2.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvayplvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydssrwtt
llirnpsrkileelystsynwdrf

Sequence, based on observed residues (ATOM records):

>d4p38b_ c.2.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
efrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaas
ahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfl
syvvltvaalpmlkqsngsivvvsslagkvayplvaaysaskfaldgffssirkeysvsr
vnvsitlcvlglidtetamkavsivhmqaapkeecaleiikggalrqeevyydssrwttl
lirnpsrkileelystsynwdrf

Timeline for d4p38b_:

• d4p38b_ is new in SCOPe 2.04-stable
  
• d4p38b_ appears in SCOPe 2.05
  
• d4p38b_ appears in the current release, SCOPe 2.08