Lineage for d4wkqa_ (4wkq A:)

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1671838Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1672833Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 1672834Species Human (Homo sapiens) [TaxId:9606] [82796] (44 PDB entries)
    Uniprot P00533 702-1018
  8. 1672844Domain d4wkqa_: 4wkq A: [260857]
    automated match to d4li5a_
    complexed with ire, mes, na

Details for d4wkqa_

PDB Entry: 4wkq (more details), 1.85 Å

PDB Description: 1.85 angstrom structure of EGFR kinase domain with gefitinib
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4wkqa_:

Sequence, based on SEQRES records: (download)

>d4wkqa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
amgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipq

Sequence, based on observed residues (ATOM records): (download)

>d4wkqa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
amgeapnqallrilketefkkikvlgsgtvykglwipegekvkipvaikespkankeild
eayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdmddvvdadeylipq

SCOPe Domain Coordinates for d4wkqa_:

Click to download the PDB-style file with coordinates for d4wkqa_.
(The format of our PDB-style files is described here.)

Timeline for d4wkqa_: