SCOPe 2.08: Domain d4wkqa1: 4wkq A:696-1020

Lineage for d4wkqa1 (4wkq A:696-1020)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d4wkqa1: 4wkq A:696-1020 [260857]
   Other proteins in same PDB: d4wkqa2
   automated match to d4li5a_
   complexed with ire, mes, na

Details for d4wkqa1

PDB Entry: 4wkq, 1.85 Å

PDB Description: 1.85 angstrom structure of EGFR kinase domain with gefitinib

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4wkqa1:

Sequence, based on SEQRES records:

>d4wkqa1 d.144.1.7 (A:696-1020) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipq

Sequence, based on observed residues (ATOM records):

>d4wkqa1 d.144.1.7 (A:696-1020) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgtvykglwipegekvkipvaikespkankeildea
yvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiak
gmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwmal
esilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidv
ymimvkcwmidadsrpkfreliiefskmardpqrylviqgdmddvvdadeylipq

Timeline for d4wkqa1:

• d4wkqa1 first appeared in SCOPe 2.04, called d4wkqa_
  
• d4wkqa1 appears in SCOPe 2.07