Lineage for d4qqca_ (4qqc A:)

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1671838Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1673984Protein automated matches [190091] (13 species)
    not a true protein
  7. 1674055Species Human (Homo sapiens) [TaxId:9606] [188447] (490 PDB entries)
  8. 1674450Domain d4qqca_: 4qqc A: [260766]
    automated match to d3ky2a_
    complexed with 37o, so4; mutant

Details for d4qqca_

PDB Entry: 4qqc (more details), 2.4 Å

PDB Description: Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
PDB Compounds: (A:) Fibroblast growth factor receptor 4

SCOPe Domain Sequences for d4qqca_:

Sequence, based on SEQRES records: (download)

>d4qqca_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dpllaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdparpdqastvav
kmlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlrefl
rarrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvte
dnvmkiadfglargvhhidyykktsngrlpvkwmapealfdevythqsdvwsfgillwei
ftlggspypgipveelfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvea
ldkvllav

Sequence, based on observed residues (ATOM records): (download)

>d4qqca_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dpllaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdqastvavkmlkd
nasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflrarrp
pgplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfgllpvkwma
pealfdevythqsdvwsfgillweiftlggspypgipveelfsllreghrmdrpphcppe
lyglmrecwhaapsqrptfkqlvealdkvllav

SCOPe Domain Coordinates for d4qqca_:

Click to download the PDB-style file with coordinates for d4qqca_.
(The format of our PDB-style files is described here.)

Timeline for d4qqca_: