SCOPe 2.06: Domain d4n9ua_: 4n9u A:

Lineage for d4n9ua_ (4n9u A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein automated matches [190489] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187688] (78 PDB entries)

8. Domain d4n9ua_: 4n9u A: [260507]
   automated match to d4demf_
   complexed with edo, mg, ris

Details for d4n9ua_

PDB Entry: 4n9u, 2.11 Å

PDB Description: The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates

PDB Compounds: (A:) farnesyl pyrophosphate synthase

SCOPe Domain Sequences for d4n9ua_:

Sequence, based on SEQRES records:

>d4n9ua_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleyntiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkygtafysfylpiaaamymagidgekehanakkillemgeffqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiy

Sequence, based on observed residues (ATOM records):

>d4n9ua_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dvyaqekqdfvqhfsqivrvltehpeigdaiarlkevleyntiggkynrgltvvvafrel
veprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaind
anlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftek
ryksivkygtafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgd
psvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlp
avflqyeedsyshimalieqyaaplppavflglarkiy

Timeline for d4n9ua_:

• d4n9ua_ first appeared in SCOPe 2.04
  
• d4n9ua_ appears in SCOPe 2.05
  
• d4n9ua_ appears in SCOPe 2.07
  
• d4n9ua_ appears in the current release, SCOPe 2.08