SCOPe 2.08: Domain d4u80a_: 4u80 A:

Lineage for d4u80a_ (4u80 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
   Uniprot Q02750 61-381

8. Domain d4u80a_: 4u80 A: [260254]
   automated match to d1s9ia_
   complexed with 3ex, anp, mg

Details for d4u80a_

PDB Entry: 4u80, 2.8 Å

PDB Description: mek 1 kinase bound to g799

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d4u80a_:

Sequence, based on SEQRES records:

>d4u80a_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssy
gmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhaf
ikrsdaeevdfagwlcsti

Sequence, based on observed residues (ATOM records):

>d4u80a_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmavgtrsymsperlqgthysvq
sdiwsmglslvemavgrypipppdakelelmfppmaifelldyivnepppklpsgvfsle
fqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcsti

Timeline for d4u80a_:

• d4u80a_ first appeared in SCOPe 2.04
  
• d4u80a_ appears in SCOPe 2.07