SCOPe 2.08: Domain d4p4ca_: 4p4c A:

Lineage for d4p4ca_ (4p4c A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4p4ca_: 4p4c A: [259913]
   automated match to d3pp0b_
   complexed with 25q

Details for d4p4ca_

PDB Entry: 4p4c, 1.6 Å

PDB Description: human epha3 kinase domain in complex with quinoxaline derivatives

PDB Compounds: (A:) EPH receptor A3

SCOPe Domain Sequences for d4p4ca_:

Sequence, based on SEQRES records:

>d4p4ca_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
akeldatnisidkvvgagefgevcsgrlklpskkeisvaiktlkvgytekqrrdflgeas
imgqfdhpniirlegvvtkskpvmivteymengsldsflrkhdaqftviqlvgmlrgias
gmkylsdmgyvhrdlaarnilinsnlvckvsdfglsrvleddpeaayttrggkipirwts
peaiayrkftsasdvwsygivlwevmsygerpywemsnqdvikavdegyrlpppmdcpaa
lyqlmldcwqkdrnnrpkfeqivsildklirnpgslkiitsaaarpsnllld

Sequence, based on observed residues (ATOM records):

>d4p4ca_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
akeldatnisidkvvgagefgevcsgrlklpskkeisvaiktlkvgytekqrrdflgeas
imgqfdhpniirlegvvtkskpvmivteymengsldsflrkhdaqftviqlvgmlrgias
gmkylsdmgyvhrdlaarnilinsnlvckvsdfpirwtspeaiayrkftsasdvwsygiv
lwevmsygerpywemsnqdvikavdegyrlpppmdcpaalyqlmldcwqkdrnnrpkfeq
ivsildklirnpgslkiitpsnllld

Timeline for d4p4ca_:

• d4p4ca_ first appeared in SCOPe 2.04
  
• d4p4ca_ appears in SCOPe 2.07