SCOPe 2.07: Domain d4ohda3: 4ohd A:219-527

Lineage for d4ohda3 (4ohd A:219-527)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (140 PDB entries)

8. Domain d4ohda3: 4ohd A:219-527 [259876]
   Other proteins in same PDB: d4ohda1, d4ohda2
   automated match to d2b3oa3
   mutant

Details for d4ohda3

PDB Entry: 4ohd, 2.7 Å

PDB Description: LEOPARD Syndrome-Associated SHP2/A461T mutant

PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4ohda3:

Sequence, based on SEQRES records:

>d4ohda3 c.45.1.0 (A:219-527) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
cstgigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietlqr

Sequence, based on observed residues (ATOM records):

>d4ohda3 c.45.1.0 (A:219-527) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhsdyinaniimpefepkksyiatqgclqntvndfwrmvfqensrvivmttkeverg
kskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtw
pdhgvpsdpggvldfleevhhkqesimdagpvvvhcstgigrtgtfividilidiirekg
vdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqr

Timeline for d4ohda3:

• d4ohda3 first appeared in SCOPe 2.04
  
• d4ohda3 appears in SCOPe 2.06
  
• d4ohda3 appears in the current release, SCOPe 2.08