Lineage for d4ohha3 (4ohh A:219-528)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2116263Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 2116264Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 2116650Family c.45.1.0: automated matches [191381] (1 protein)
    not a true family
  6. 2116651Protein automated matches [190475] (8 species)
    not a true protein
  7. 2116663Species Human (Homo sapiens) [TaxId:9606] [187400] (116 PDB entries)
  8. 2116801Domain d4ohha3: 4ohh A:219-528 [259868]
    Other proteins in same PDB: d4ohha1, d4ohha2
    automated match to d2b3oa3
    mutant

Details for d4ohha3

PDB Entry: 4ohh (more details), 2.7 Å

PDB Description: LEOPARD Syndrome-Associated SHP2/Q506P mutant
PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4ohha3:

Sequence, based on SEQRES records: (download)

>d4ohha3 c.45.1.0 (A:219-528) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvpteaqyrfiymav
qhyietlqrr

Sequence, based on observed residues (ATOM records): (download)

>d4ohha3 c.45.1.0 (A:219-528) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtr
vvlhdsdyinaniimpekksyiatqgclqntvndfwrmvfqensrvivmttkevergksk
cvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdh
gvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdc
didvpktiqmvrsqrsgmvpteaqyrfiymavqhyietlqrr

SCOPe Domain Coordinates for d4ohha3:

Click to download the PDB-style file with coordinates for d4ohha3.
(The format of our PDB-style files is described here.)

Timeline for d4ohha3: