SCOPe 2.08: Domain d4cx0a_: 4cx0 A:

Lineage for d4cx0a_ (4cx0 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.174: Nitric oxide (NO) synthase oxygenase domain [56511] (1 superfamily)
   unusual fold

4. Superfamily d.174.1: Nitric oxide (NO) synthase oxygenase domain [56512] (1 family)
   automatically mapped to Pfam PF02898

5. Family d.174.1.1: Nitric oxide (NO) synthase oxygenase domain [56513] (2 proteins)

6. Protein automated matches [190421] (6 species)
   not a true protein

7. Species Cow (Bos taurus) [TaxId:9913] [188827] (44 PDB entries)

8. Domain d4cx0a_: 4cx0 A: [259347]
   automated match to d3e7sa_
   complexed with act, gol, h4b, hem, q16, zn; mutant

Details for d4cx0a_

PDB Entry: 4cx0, 2.2 Å

PDB Description: structure of bovine endothelial nitric oxide synthase y477a mutant heme domain in complex with 6-((((3s, 5r)-5-(((6-amino-4- methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4- methylpyridin-2-amine

PDB Compounds: (A:) Nitric oxide synthase, endothelial

SCOPe Domain Sequences for d4cx0a_:

Sequence, based on SEQRES records:

>d4cx0a_ d.174.1.1 (A:) automated matches {Cow (Bos taurus) [TaxId: 9913]}
gpkfprvknwelgsitydtlcaqsqqdgpctprrclgslvlprklqtrpspgpppaeqll
sqardfinqyyssikrsgsqaheerlqeveaevastgtyhlreselvfgakqawrnaprc
vgriqwgklqvfdardcssaqemftyicnhikyatnrgnlrsaitvfpqrapgrgdfriw
nsqlvryagyrqqdgsvrgdpanveitelciqhgwtpgngrfdvlplllqapdeapelfv
lppelvlevplehptlewfaalglrwyalpavsnmlleigglefsaapfsgwymsteigt
rnlcdphryniledvavcmdldtrttsslwkdkaaveinlavlhsfqlakvtivdhhaat
vsfmkhldneqkarggcpadwawivppisgsltpvfhqemvnyilspafraqpdpw

Sequence, based on observed residues (ATOM records):

>d4cx0a_ d.174.1.1 (A:) automated matches {Cow (Bos taurus) [TaxId: 9913]}
gpkfprvknwelgsitydtlcaqsqqdgpctprrclgslvlprpaeqllsqardfinqyy
ssikrsgsqaheerlqeveaevastgtyhlreselvfgakqawrnaprcvgriqwgklqv
fdardcssaqemftyicnhikyatnrgnlrsaitvfpqrapgrgdfriwnsqlvryagyr
qqdgsvrgdpanveitelciqhgwtpgngrfdvlplllqapdeapelfvlppelvlevpl
ehptlewfaalglrwyalpavsnmlleigglefsaapfsgwymsteigtrnlcdphryni
ledvavcmdldtrttsslwkdkaaveinlavlhsfqlakvtivdhhaatvsfmkhldneq
karggcpadwawivppisgsltpvfhqemvnyilspafraqpdpw

Timeline for d4cx0a_:

• d4cx0a_ first appeared in SCOPe 2.04
  
• d4cx0a_ appears in SCOPe 2.07