SCOPe 2.04: Domain d4c0ca_: 4c0c A:

Lineage for d4c0ca_ (4c0c A:)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (40 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:5693] [196511] (9 PDB entries)

8. Domain d4c0ca_: 4c0c A: [259324]
   automated match to d3khma_
   complexed with gol, hem, so4, wvh

Details for d4c0ca_

PDB Entry: 4c0c, 2.04 Å

PDB Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(2,4-difluorophenyl)piperazin-1-yl)-2-fluorobenzamide.

PDB Compounds: (A:) Sterol 14-alpha demethylase

SCOPe Domain Sequences for d4c0ca_:

Sequence, based on SEQRES records:

>d4c0ca_ a.104.1.0 (A:) automated matches {Trypanosoma cruzi [TaxId: 5693]}
gklppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsr
ffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqh
evrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmessl
ipaavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllka
vyrdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpa
qlnydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllsh
hdeeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqll
rdevpdpdyhtmvvgptlnqclvkytrkkk

Sequence, based on observed residues (ATOM records):

>d4c0ca_ a.104.1.0 (A:) automated matches {Trypanosoma cruzi [TaxId: 5693]}
gklppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsr
ffsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqh
evrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmessl
ipaavfmpwllrlplpqsarcrearaelqkilgeiivarekeeastsdllggllkavyrd
gtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlny
dnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdee
afpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdev
pdpdyhtmvvgptlnqclvkytrkkk

Timeline for d4c0ca_:

• d4c0ca_ is new in SCOPe 2.04-stable
  
• d4c0ca_ appears in SCOPe 2.05
  
• d4c0ca_ appears in the current release, SCOPe 2.08, called d4c0ca1