SCOPe 2.05: Domain d4ny9a_: 4ny9 A:

Lineage for d4ny9a_ (4ny9 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Pregnane x receptor, PXR [63624] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63625] (15 PDB entries)

8. Domain d4ny9a_: 4ny9 A: [259232]
   automated match to d1m13a_
   complexed with 2q4, gol

Details for d4ny9a_

PDB Entry: 4ny9, 2.8 Å

PDB Description: crystal structure of the human pxr-lbd in complex with n-{(2r)-1- [(4s)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3- methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide

PDB Compounds: (A:) Nuclear receptor subfamily 1 group I member 2

SCOPe Domain Sequences for d4ny9a_:

Sequence, based on SEQRES records:

>d4ny9a_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgvlssgcelpeslqapsreeaakwsq
vrkdlcslkvslqlrgedgsvwnykppadsggkeifsllphmadmstymfkgiisfakvi
syfrdlpiedqisllkgaafelcqlrfntvfnaetgtwecgrlsycledtaggfqqllle
pmlkfhymlkklqlheeeyvlmqaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnr
pqpahrflflkimamltelrsinaqhtqrllriqdihpfatplmqelfgi

Sequence, based on observed residues (ATOM records):

>d4ny9a_ a.123.1.1 (A:) Pregnane x receptor, PXR {Human (Homo sapiens) [TaxId: 9606]}
glteeqrmmirelmdaqmktfdttfshfknfrlpgqvrkdlcslkvslqlrgedgsvwny
kppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisllkgaafelcq
lrfntvfnaetgtwecgrlsycleqqlllepmlkfhymlkklqlheeeyvlmqaislfsp
drpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrsinaqhtqrl
lriqdihpfatplmqelfgi

Timeline for d4ny9a_:

• d4ny9a_ first appeared in SCOPe 2.04
  
• d4ny9a_ appears in SCOPe 2.06
  
• d4ny9a_ appears in the current release, SCOPe 2.08