Lineage for d4jefa_ (4jef A:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2972108Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2972109Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2972110Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 2972208Protein Thymidylate synthase [55833] (7 species)
  7. 2972355Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)
  8. 2972408Domain d4jefa_: 4jef A: [259067]
    automated match to d1hvya_
    complexed with so4

Details for d4jefa_

PDB Entry: 4jef (more details), 2.31 Å

PDB Description: crystal structure of human thymidylate synthase y202a in inactive conformation.
PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d4jefa_:

Sequence, based on SEQRES records: (download)

>d4jefa_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfavvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem

Sequence, based on observed residues (ATOM records): (download)

>d4jefa_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelslgpvygfqwrhfysgqgvdqlqrvidtiktnpddrriimcawn
prdlplmalppchalcqfavvnselscqlyqrsgdmglgvpfniasyalltymiahitgl
kpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynp
hptikmem

SCOPe Domain Coordinates for d4jefa_:

Click to download the PDB-style file with coordinates for d4jefa_.
(The format of our PDB-style files is described here.)

Timeline for d4jefa_: