SCOPe 2.08: Domain d4tthb_: 4tth B:

Lineage for d4tthb_ (4tth B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK6 [88859] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88860] (16 PDB entries)

8. Domain d4tthb_: 4tth B: [258840]
   Other proteins in same PDB: d4ttha1, d4ttha2
   automated match to d1blxa_
   complexed with 24v

Details for d4tthb_

PDB Entry: 4tth, 2.9 Å

PDB Description: crystal structure of a cdk6/vcyclin complex with inhibitor bound

PDB Compounds: (B:) cyclin-dependent kinase 6

SCOPe Domain Sequences for d4tthb_:

Sequence, based on SEQRES records:

>d4tthb_ d.144.1.7 (B:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
cvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhletfehp
nvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgld
flhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrapevllqs
syatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdvalprqaf
hsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfqdle

Sequence, based on observed residues (ATOM records):

>d4tthb_ d.144.1.7 (B:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
cvaeigekvfkardlkngrfvalkrvrvegmplstirevavlrhletfehpnvvrlfdvc
ttkltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgldflhshrvvhrdlkpqn
ilvtssgqikladfglariysfqmaltsvvvtlwyrapevllqssyatpvdlwsvgcifa
emfrrkplfrgssdvdqlgkildviglpgeedwppiekfdidelgkdlllkcltfnpakr
isaysalshpyfqdle

Timeline for d4tthb_:

• d4tthb_ first appeared in SCOPe 2.04
  
• d4tthb_ appears in SCOPe 2.07