SCOPe 2.05: Domain d4qa2a_: 4qa2 A:

Lineage for d4qa2a_ (4qa2 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (24 PDB entries)

8. Domain d4qa2a_: 4qa2 A: [258790]
   automated match to d2v5wb_
   complexed with gol, k, shh, zn

Details for d4qa2a_

PDB Entry: 4qa2, 2.38 Å

PDB Description: Crystal structure of I243N HDAC8 in complex with SAHA

PDB Compounds: (A:) Histone deacetylase 8

SCOPe Domain Sequences for d4qa2a_:

Sequence, based on SEQRES records:

>d4qa2a_ c.42.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqncesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvvi

Sequence, based on observed residues (ATOM records):

>d4qa2a_ c.42.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegyglgydcpategifdyaaaiggatitaaqclidgmckvainwsggwh
hakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslhk
fspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqncesvlkevyqafnpkavvl
qlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltgvi
lgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvvi

Timeline for d4qa2a_:

• d4qa2a_ first appeared in SCOPe 2.04
  
• d4qa2a_ is called d4qa2a1 in SCOPe 2.06
  
• d4qa2a_ appears in the current release, SCOPe 2.08, called d4qa2a1