SCOPe 2.08: Domain d4ov6e_: 4ov6 E:

Lineage for d4ov6e_ (4ov6 E:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.41: Subtilisin-like [52742] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3

4. Superfamily c.41.1: Subtilisin-like [52743] (3 families)

5. Family c.41.1.1: Subtilases [52744] (15 proteins)

6. Protein Proprotein convertase subtilisin/kexin type 9 [419231] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419292] (20 PDB entries)

8. Domain d4ov6e_: 4ov6 E: [258045]
   Other proteins in same PDB: d4ov6f_, d4ov6g_
   automated match to d2w2na_
   complexed with edo, pg4

Details for d4ov6e_

PDB Entry: 4ov6, 2.69 Å

PDB Description: crystal structure of pcsk9(53-451) with adnectin

PDB Compounds: (E:) Proprotein convertase subtilisin/kexin type 9

SCOPe Domain Sequences for d4ov6e_:

Sequence, based on SEQRES records:

>d4ov6e_ c.41.1.1 (E:) Proprotein convertase subtilisin/kexin type 9 {Human (Homo sapiens) [TaxId: 9606]}
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalp

Sequence, based on observed residues (ATOM records):

>d4ov6e_ c.41.1.1 (E:) Proprotein convertase subtilisin/kexin type 9 {Human (Homo sapiens) [TaxId: 9606]}
sipwnleritplvevylldtsiqsdhreiegrvmvtdfenvpeedskcdshgthlagvvs
grdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggysr
vlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgtnf
grcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepeltlaelrqrl
ihfsakdvineawfpedqrvltpnlvaalp

Timeline for d4ov6e_:

• d4ov6e_ first appeared in SCOPe 2.04
  
• d4ov6e_ appears in SCOPe 2.07