Lineage for d4puza_ (4puz A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2545010Protein Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  7. 2545011Species Human (Homo sapiens) [TaxId:9606] [118132] (64 PDB entries)
    Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)
  8. 2545053Domain d4puza_: 4puz A: [257562]
    automated match to d1xbba_
    complexed with cg9

Details for d4puza_

PDB Entry: 4puz (more details), 2.08 Å

PDB Description: Crystal structure of spleen tyrosine kinase (Syk) in complex with GS-9973
PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4puza_:

Sequence, based on SEQRES records: (download)

>d4puza_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydv

Sequence, based on observed residues (ATOM records): (download)

>d4puza_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqql
dnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylee
snfvhrdlaarnvllvtqhyakisdfglskalradenyykaqkwpvkwyapecinyykfs
sksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwt
ydvenrpgfaavelrlrnyyydv

SCOPe Domain Coordinates for d4puza_:

Click to download the PDB-style file with coordinates for d4puza_.
(The format of our PDB-style files is described here.)

Timeline for d4puza_: