Lineage for d4n4sa_ (4n4s A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1930838Protein MAP kinase Erk2 [56134] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 1930860Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (27 PDB entries)
  8. 1930887Domain d4n4sa_: 4n4s A: [257124]
    automated match to d1erka_
    complexed with 2h1; mutant

Details for d4n4sa_

PDB Entry: 4n4s (more details), 2.2 Å

PDB Description: A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor
PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4n4sa_:

Sequence, based on SEQRES records: (download)

>d4n4sa_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
gpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtl
reikillrfrheniigindiiraptieqmkdvyivadlmetdlykllktqhlsndhicyf
lyqilrglkyihsanvlhrdlkpsnlllnttcdlkildfglarvadpdhdhtgflteyva
trwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsq
edlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqala
hpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy

Sequence, based on observed residues (ATOM records): (download)

>d4n4sa_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
gpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtl
reikillrfrheniigindiiraptieqmkdvyivadlmetdlykllktqhlsndhicyf
lyqilrglkyihsanvlhrdlkpsnlllnttcdlkildfglarvadpdteyvatrwyrap
eimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlncii
nlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqy
ydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy

SCOPe Domain Coordinates for d4n4sa_:

Click to download the PDB-style file with coordinates for d4n4sa_.
(The format of our PDB-style files is described here.)

Timeline for d4n4sa_: