Lineage for d4m8yb_ (4m8y B:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2058816Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 protein domains)
    dimer of identical mono-domain chains, each containing (6,10) barrel
  6. 2058832Protein Human immunodeficiency virus type 1 protease [50632] (9 species)
  7. 2059066Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (476 PDB entries)
    Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167
  8. 2059894Domain d4m8yb_: 4m8y B: [257076]
    automated match to d2rkga_
    complexed with kgq; mutant

Details for d4m8yb_

PDB Entry: 4m8y (more details), 2.22 Å

PDB Description: GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits HIV PR Mutants with Amino Acid Insertions
PDB Compounds: (B:) Protease

SCOPe Domain Sequences for d4m8yb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4m8yb_ b.50.1.1 (B:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}

SCOPe Domain Coordinates for d4m8yb_:

Click to download the PDB-style file with coordinates for d4m8yb_.
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Timeline for d4m8yb_: