SCOPe 2.08: Domain d4kpwa_: 4kpw A:

Lineage for d4kpwa_ (4kpw A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)

8. Domain d4kpwa_: 4kpw A: [256891]
   automated match to d4eb4a_
   complexed with edo, so4; mutant

Details for d4kpwa_

PDB Entry: 4kpw, 2.03 Å

PDB Description: crystal structure of his-tagged human thymidylate synthase r175a mutant

PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d4kpwa_:

Sequence, based on SEQRES records:

>d4kpwa_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddariimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem

Sequence, based on observed residues (ATOM records):

>d4kpwa_ d.117.1.1 (A:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvid
tiktnpddariimcawnprdlplmalppchalcqfyvvnselscqlyqrsgdmglgvpfn
iasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkve
kiddfkaedfqiegynphptikmem

Timeline for d4kpwa_:

• d4kpwa_ first appeared in SCOPe 2.04
  
• d4kpwa_ appears in SCOPe 2.07