SCOPe 2.08: Domain d4knbb_: 4knb B:

Lineage for d4knbb_ (4knb B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d4knbb_: 4knb B: [256878]
   automated match to d3f66a_
   complexed with 1ru, gbl

Details for d4knbb_

PDB Entry: 4knb, 2.4 Å

PDB Description: C-Met in complex with OSI ligand

PDB Compounds: (B:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d4knbb_:

Sequence, based on SEQRES records:

>d4knbb_ d.144.1.7 (B:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnritdigevsqflt
egiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdligfgl
qvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvhnktgaklp
vkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpe
ycpdplyevmlkcwhpkaemrpsfselvsrisaifstfig

Sequence, based on observed residues (ATOM records):

>d4knbb_ d.144.1.7 (B:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
qhvvigpsslivhfnevigrghfgcvyhgtllkihcavksigevsqfltegiimkdfshp
nvlsllgicplvvlpymkhgdlrnfirnethnptvkdligfglqvakgmkylaskkfvhr
dlaarncmldekftvkvadfglardmydkeyysvlpvkwmaleslqtqkfttksdvwsfg
vllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsf
selvsrisaifstfig

Timeline for d4knbb_:

• d4knbb_ first appeared in SCOPe 2.04
  
• d4knbb_ appears in SCOPe 2.07