SCOPe 2.07: Domain d4kfaa_: 4kfa A:

Lineage for d4kfaa_ (4kfa A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein automated matches [190489] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187688] (85 PDB entries)

8. Domain d4kfaa_: 4kfa A: [256850]
   automated match to d4demf_
   complexed with edo, mg, zol; mutant

Details for d4kfaa_

PDB Entry: 4kfa, 1.98 Å

PDB Description: Crystal structure of human farnesyl pyrophosphate synthase (t201a mutant) complexed with mg and zoledronate

PDB Compounds: (A:) farnesyl pyrophosphate synthase

SCOPe Domain Sequences for d4kfaa_:

Sequence, based on SEQRES records:

>d4kfaa_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvvaf
relveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvglda
indanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrf
tekryksivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldl
fgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeel
dlpavflqyeedsyshimalieqyaaplppavflglarkiyk

Sequence, based on observed residues (ATOM records):

>d4kfaa_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vyaqekqdfvqhfsqivrvltehpeigdaiarlkevleynaiggkynrgltvvvafrelv
eprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldainda
nlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekr
yksivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdp
svtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpa
vflqyeedsyshimalieqyaaplppavflglarkiyk

Timeline for d4kfaa_:

• d4kfaa_ first appeared in SCOPe 2.04
  
• d4kfaa_ appears in SCOPe 2.06
  
• d4kfaa_ appears in the current release, SCOPe 2.08