SCOPe 2.06: Domain d4ckuc_: 4cku C:

Lineage for d4ckuc_ (4cku C:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Plasmepsin (a hemoglobin-degrading enzyme) [50673] (3 species)

7. Species Plasmodium falciparum, plasmepsin II [TaxId:5833] [50674] (22 PDB entries)

8. Domain d4ckuc_: 4cku C: [256628]
   automated match to d1leea_
   complexed with p2f

Details for d4ckuc_

PDB Entry: 4cku, 1.85 Å

PDB Description: three dimensional structure of plasmepsin ii in complex with hydroxyethylamine-based inhibitor

PDB Compounds: (C:) Plasmepsin-2

SCOPe Domain Sequences for d4ckuc_:

Sequence, based on SEQRES records:

>d4ckuc_ b.50.1.2 (C:) Plasmepsin (a hemoglobin-degrading enzyme) {Plasmodium falciparum, plasmepsin II [TaxId: 5833]}
sndnielvdfqnimfygdaevgdnqqpftfildtgsanlwvpsvkcttagcltkhlydss
ksrtyekdgtkvemnyvsgtvsgffskdlvtvgnlslpykfievidtngfeptytastfd
gilglgwkdlsigsvdpivvelknqnkienalftfylpvhdkhtgfltiggieerfyegp
ltyeklnhdlywqitldahvgnislekancivdsgtsaitvptdflnkmlqnldvikvpf
lpfyvtlcnnsklptfeftsengkytlepeyylqhiedvgpglcmlniigldfpvptfil
gdpfmrkyftvfdydnhsvgialakknl

Sequence, based on observed residues (ATOM records):

>d4ckuc_ b.50.1.2 (C:) Plasmepsin (a hemoglobin-degrading enzyme) {Plasmodium falciparum, plasmepsin II [TaxId: 5833]}
sndnielvdfqnimfygdaevgdnqqpftfildtgsanlwvpsvkcttagcltkhlydss
ksrtyekdgtkvemnyvsgtvsgffskdlvtvgnlslpykfievidtngfeptytastfd
gilglgwkdlsigsvdpivvelknqnkienalftfylpvhdkhtgfltiggieerfyegp
ltyeklnhdlywqitldahvgnislekancivdsgtsaitvptdflnkmlqnldvikvpf
lpfyvtlcnnsklptfeftsengkytlepeyylqhilcmlniigldfpvptfilgdpfmr
kyftvfdydnhsvgialakknl

Timeline for d4ckuc_:

• d4ckuc_ first appeared in SCOPe 2.04
  
• d4ckuc_ appears in SCOPe 2.05
  
• d4ckuc_ appears in SCOPe 2.07
  
• d4ckuc_ appears in the current release, SCOPe 2.08