SCOPe 2.05: Protein: alpha-2-macroglobulin

Lineage for Protein: alpha-2-macroglobulin

Root: SCOPe 2.05
Class b: All beta proteins [48724] (176 folds)
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands

Superfamily b.1.29: Macroglobulin [254121] (8 families)

C3 MG domains possibly arose by gene duplication according to PubMed 16177781; PubMed 17608619; possibly related to immunoglobulins according to Pfam clan annotations

Family b.1.29.1: Alpha-macroglobulin receptor domain [254148] (4 proteins)
Pfam PF07677
Protein alpha-2-macroglobulin [254336] (2 species)

Species:

Cow (Bos taurus) [TaxId:9913] [254767] (1 PDB entry)
- Domains for 1ayo:
  1. Domain d1ayoa_: 1ayo A: [22431]
    complexed with ca
  2. Domain d1ayob_: 1ayo B: [22432]
    complexed with ca
Human (Homo sapiens) [TaxId:9606] [254768] (1 PDB entry)
- Domain for 1bv8:
  - Domain d1bv8a_: 1bv8 A: [22430]

More info for Protein alpha-2-macroglobulin from b.1.29.1: Alpha-macroglobulin receptor domain

Timeline for Protein alpha-2-macroglobulin from b.1.29.1: Alpha-macroglobulin receptor domain:

Protein alpha-2-macroglobulin from b.1.29.1: Alpha-macroglobulin receptor domain first appeared in SCOPe 2.04
Protein alpha-2-macroglobulin from b.1.29.1: Alpha-macroglobulin receptor domain appears in SCOPe 2.06
Protein alpha-2-macroglobulin from b.1.29.1: Alpha-macroglobulin receptor domain appears in the current release, SCOPe 2.08