SCOPe 2.08: Family b.82.2.14: Jumonji domain / Histone demethylase core

Lineage for Family b.82.2.14: Jumonji domain / Histone demethylase core

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.14: Jumonji domain / Histone demethylase core [254153] (7 proteins)
   Jumonji domain; Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801
   Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801; some members include C-terminal helical subdomain (Pfam PF17811)

Proteins:

1. JHDM1A core [419130] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [419652] (2 PDB entries)

2. JHDM2B core [254344] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [254777] (1 PDB entry)

3. JMJD2A core [254342] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [254775] (57 PDB entries)

4. JMJD2D core [254343] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [254776] (275 PDB entries)

5. KDM5B (JARID1B or PLU1) core [419085] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [419582] (14 PDB entries)

6. PHD finger protein 8 (PHF8) [419131] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [419653] (1 PDB entry)

7. automated matches [254635] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [255633] (100 PDB entries)

More info for Family b.82.2.14: Jumonji domain / Histone demethylase core

Timeline for Family b.82.2.14: Jumonji domain / Histone demethylase core:

• Family b.82.2.14: Jumonji domain / Histone demethylase core first appeared in SCOPe 2.04, called Family b.82.2.14: Histone demethylase core
  
• Family b.82.2.14: Jumonji domain / Histone demethylase core was called Family b.82.2.14: Histone demethylase core in SCOPe 2.07