Lineage for d4mpna2 (4mpn A:182-394)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2579776Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
    8-stranded mixed beta-sheet; 2 layers: alpha/beta
  4. 2579777Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families) (S)
  5. 2580489Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)
  6. 2580507Protein Pyruvate dehydrogenase kinase [69807] (2 species)
  7. 2580508Species Human (Homo sapiens) [TaxId:9606] [160702] (19 PDB entries)
    Uniprot Q15120 177-301
  8. 2580512Domain d4mpna2: 4mpn A:182-394 [253826]
    Other proteins in same PDB: d4mpna1
    automated match to d2bu8a2
    complexed with pv0, tla

Details for d4mpna2

PDB Entry: 4mpn (more details), 1.75 Å

PDB Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS10
PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d4mpna2:

Sequence, based on SEQRES records: (download)

>d4mpna2 d.122.1.4 (A:182-394) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyv
pshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkie
rlfsymystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylk
alstdsverlpvynksawrhyqtiqeagdwcvp

Sequence, based on observed residues (ATOM records): (download)

>d4mpna2 d.122.1.4 (A:182-394) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
pahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyv
pshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkie
rlfsymystgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynks
awrhyqtiqeagdwcvp

SCOPe Domain Coordinates for d4mpna2:

Click to download the PDB-style file with coordinates for d4mpna2.
(The format of our PDB-style files is described here.)

Timeline for d4mpna2:

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Domains from same chain:
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d4mpna1