SCOPe 2.05: Domain d4l5bb_: 4l5b B:

Lineage for d4l5bb_ (4l5b B:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Deoxycytidine kinase [89657] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89658] (41 PDB entries)

8. Domain d4l5bb_: 4l5b B: [253526]
   automated match to d1p60a_
   complexed with 1ux, udp; mutant

Details for d4l5bb_

PDB Entry: 4l5b, 1.94 Å

PDB Description: Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor

PDB Compounds: (B:) Deoxycytidine kinase

SCOPe Domain Sequences for d4l5bb_:

Sequence, based on SEQRES records:

>d4l5bb_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmeqkngg
nvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifas
nlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqg
ipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflst
l

Sequence, based on observed residues (ATOM records):

>d4l5bb_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsltmeqknggnvlqmmyekpe
rwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnet
ewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhy
kheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

Timeline for d4l5bb_:

• d4l5bb_ first appeared in SCOPe 2.04
  
• d4l5bb_ appears in SCOPe 2.06
  
• d4l5bb_ appears in the current release, SCOPe 2.08