SCOPe 2.05: Domain d4ky8a2: 4ky8 A:193-521

Lineage for d4ky8a2 (4ky8 A:193-521)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)

8. Domain d4ky8a2: 4ky8 A:193-521 [253461]
   Other proteins in same PDB: d4ky8a1, d4ky8b1, d4ky8c1, d4ky8d1, d4ky8e1
   automated match to d1qzfa2
   complexed with 1uf, mtx, ndp, ufp

Details for d4ky8a2

PDB Entry: 4ky8, 3.08 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, methotrexate, fdump and 4-((2-amino-6-methyl-4-oxo-4,7- dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-l- glutamic acid

PDB Compounds: (A:) Bifunctional thymidylate synthase-dihydrofolate reductase

SCOPe Domain Sequences for d4ky8a2:

Sequence; same for both SEQRES and ATOM records:

>d4ky8a2 d.117.1.1 (A:193-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
lksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlenga
yrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekk
vyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlakli
etlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgsp
fniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrk
veniedfkwedieligyypyptikmdmav

Timeline for d4ky8a2:

• d4ky8a2 first appeared in SCOPe 2.04
  
• d4ky8a2 appears in SCOPe 2.06
  
• d4ky8a2 appears in the current release, SCOPe 2.08