SCOPe 2.05: Domain d4jlxa1: 4jlx A:135-382

Lineage for d4jlxa1 (4jlx A:135-382)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.218: Nucleotidyltransferase [81302] (1 superfamily)
   core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order of core strands: 123

4. Superfamily d.218.1: Nucleotidyltransferase [81301] (16 families)

5. Family d.218.1.15: cGAMP synthase, cGAS N-terminal domain [254174] (1 protein)
   Pfam PF03281; PubMed 23647843; structurally very similar to hOAS1 (d.218.1.6)

6. Protein cGAMP synthase, cGAS N-terminal domain [254394] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [256336] (2 PDB entries)

8. Domain d4jlxa1: 4jlx A:135-382 [252974]
   Other proteins in same PDB: d4jlxa2
   automated match to d4k8va1
   complexed with gol, mli, pg4, zn

Details for d4jlxa1

PDB Entry: 4jlx, 2 Å

PDB Description: Structure of porcine cyclic GMP-AMP synthase (cGAS)

PDB Compounds: (A:) Uncharacterized protein

SCOPe Domain Sequences for d4jlxa1:

Sequence, based on SEQRES records:

>d4jlxa1 d.218.1.15 (A:135-382) cGAMP synthase, cGAS N-terminal domain {Pig (Sus scrofa) [TaxId: 9823]}
gawklqtvlekvrlsrheiseaaevvnwvvehllrrlqggesefkgvallrtgsyyervk
isapnefdvmfklevpriqleeycnsgahyfvkfkrnpggnpleqflekeilsaskmlsk
frkiikeeikniedtgvtverkrrgspavtlliskpkeisvdiilalesksswpastqkg
lpisqwlgakvknnlkrqpfylvpkhakegsgfqeetwrlsfshiekdilknhgqsktcc
eidgvkcc

Sequence, based on observed residues (ATOM records):

>d4jlxa1 d.218.1.15 (A:135-382) cGAMP synthase, cGAS N-terminal domain {Pig (Sus scrofa) [TaxId: 9823]}
gawklqtvlekvrlsrheiseaaevvnwvvehllrrlqggesefkgvallrtgsapnefd
vmfklevpriqleeycnsgahyfvkfkrnpggnpleqflekeilsaskmlskfrkiikee
ikntgvtverkrgspavtlliskpkeisvdiilalesksswpastqkglpisqwlgakvk
nnlkrqpfylvpkhakegsgfqeetwrlsfshiekdilknhgqsktcceidgvkcc

Timeline for d4jlxa1:

• d4jlxa1 first appeared in SCOPe 2.04
  
• d4jlxa1 appears in SCOPe 2.06
  
• d4jlxa1 appears in the current release, SCOPe 2.08