SCOPe 2.05: Domain d4jlma_: 4jlm A:

Lineage for d4jlma_ (4jlm A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Deoxycytidine kinase [89657] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89658] (41 PDB entries)

8. Domain d4jlma_: 4jlm A: [252970]
   automated match to d1p60a_
   complexed with 1nn, udp; mutant

Details for d4jlma_

PDB Entry: 4jlm, 2.18 Å

PDB Description: human dck c4s-s74e mutant in complex with udp and the f2.3.1 inhibitor (2-[({5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine)

PDB Compounds: (A:) Deoxycytidine kinase

SCOPe Domain Sequences for d4jlma_:

Sequence, based on SEQRES records:

>d4jlma_ c.37.1.1 (A:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmeqkng
gnvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifa
snlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeq
gipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkefls
tl

Sequence, based on observed residues (ATOM records):

>d4jlma_ c.37.1.1 (A:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsneltmeqknggnvlqmmye
kperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesm
netewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleylek
lhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

Timeline for d4jlma_:

• d4jlma_ first appeared in SCOPe 2.04
  
• d4jlma_ appears in SCOPe 2.06
  
• d4jlma_ appears in the current release, SCOPe 2.08