SCOPe 2.04: Domain d4j7ub_: 4j7u B:

Lineage for d4j7ub_ (4j7u B:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Sepiapterin reductase [51767] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [141874] (4 PDB entries)
   Uniprot P35270 5-261

8. Domain d4j7ub_: 4j7u B: [252836]
   automated match to d1z6za1
   complexed with gol, nap, peg, so4, ytz

Details for d4j7ub_

PDB Entry: 4j7u, 2.44 Å

PDB Description: Crystal structure of human sepiapterin reductase in complex with sulfathiazole

PDB Compounds: (B:) sepiapterin reductase

SCOPe Domain Sequences for d4j7ub_:

Sequence; same for both SEQRES and ATOM records:

>d4j7ub_ c.2.1.2 (B:) Sepiapterin reductase {Human (Homo sapiens) [TaxId: 9606]}
glgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaersglrv
vrvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnny
walnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqv
laleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqklls
llekdefksgahvdfyd

Timeline for d4j7ub_:

• d4j7ub_ is new in SCOPe 2.04-stable
  
• d4j7ub_ appears in SCOPe 2.05
  
• d4j7ub_ appears in the current release, SCOPe 2.08