SCOPe 2.08: Domain d4itha_: 4ith A:

Lineage for d4itha_ (4ith A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4itha_: 4ith A: [252694]
   automated match to d4itja_
   complexed with iod, na, rcm

Details for d4itha_

PDB Entry: 4ith, 2.25 Å

PDB Description: Crystal structure of RIP1 kinase in complex with necrostatin-1 analog

PDB Compounds: (A:) Receptor-interacting serine/threonine-protein kinase 1

SCOPe Domain Sequences for d4itha_:

Sequence, based on SEQRES records:

>d4itha_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nvikmkssdflesaeldsggfgkvslafhrtqglmimktvykgpnciehnealleeakmm
nrlrhsrvvkllgviieegkyslvmeymekgnlmhvlkaemstplsvkgriileiiegma
ylhgkgvihkdlkpenilvdndfhikiadlglasfkmwsklnneehnelrevdgtakkng
gtlyymapehlndvnakpteksdvysfavvlwaifankepyenaiaeqqlimaiksgnrp
dvdditeycpreiislmklcweanpearptfpgieekfrpfylsqle

Sequence, based on observed residues (ATOM records):

>d4itha_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nvikmkssdflvslafhrtqglmimktvnealleeakmmnrlrhsrvvkllgviieegky
slvmeymekgnlmhvlkaemstplsvkgriileiiegmaylhgkgvihkdlkpenilvdn
dfhikiadlglasfkmwsklgtlyymapehlndvnakpteksdvysfavvlwaifankep
yenaiaeqqlimaiksgnrpdvdditeycpreiislmklcweanpearptfpgieekfrp
fylsqle

Timeline for d4itha_:

• d4itha_ first appeared in SCOPe 2.04
  
• d4itha_ appears in SCOPe 2.07