SCOPe 2.04: Domain d4is2a_: 4is2 A:

Lineage for d4is2a_ (4is2 A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.0: automated matches [191313] (1 protein)
   not a true family

6. Protein automated matches [190069] (181 species)
   not a true protein

7. Species Clostridium scindens [TaxId:29347] [234900] (2 PDB entries)

8. Domain d4is2a_: 4is2 A: [252691]
   automated match to d4is3a_
   complexed with cl

Details for d4is2a_

PDB Entry: 4is2, 1.9 Å

PDB Description: crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (baia2) associated with secondary bile acid synthesis from clostridium scindens vpi12708 at 1.90 a resolution

PDB Compounds: (A:) Bile acid 3-alpha hydroxysteroid dehydrogenase

SCOPe Domain Sequences for d4is2a_:

Sequence, based on SEQRES records:

>d4is2a_ c.2.1.0 (A:) automated matches {Clostridium scindens [TaxId: 29347]}
mnlvqdkvtiitggtrgigfaaakifidngakvsifgetqeevdtalaqlkelypeeevl
gfapdltsrdavmaavgqvaqkygrldvminnagitsnnvfsrvseeefkhimdinvtgv
fngawcayqcmkdakkgviintasvtgifgslsgvgypaskasviglthglgreiirkni
rvvgvapgvvntdmtngnppeimegylkalpmkrmlepeeianvylflasdlasgitatt
vsvdg

Sequence, based on observed residues (ATOM records):

>d4is2a_ c.2.1.0 (A:) automated matches {Clostridium scindens [TaxId: 29347]}
mnlvqdkvtiitggtrgigfaaakifidngakvsifgetqeevdtalaqlkelypeeevl
gfapdltsrdavmaavgqvaqkygrldvminnagitsnnvfsrvseeefkhimdinvtgv
fngawcayqcmkdakkgviintasvtgifpaskasviglthglgreiirknirvvgvapg
vvntmlepeeianvylflasdlasgitattvsvdg

Timeline for d4is2a_:

• d4is2a_ is new in SCOPe 2.04-stable
  
• d4is2a_ appears in SCOPe 2.05
  
• d4is2a_ appears in the current release, SCOPe 2.08