SCOPe 2.04: Domain d4iq6a_: 4iq6 A:

Lineage for d4iq6a_ (4iq6 A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (35 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d4iq6a_: 4iq6 A: [252670]
   automated match to d1j1bb_
   complexed with iq6

Details for d4iq6a_

PDB Entry: 4iq6, 3.12 Å

PDB Description: gsk-3beta with inhibitor 6-chloro-n-cyclohexyl-4-(1h-pyrrolo[2,3- b]pyridin-3-yl)pyridin-2-amine

PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d4iq6a_:

Sequence, based on SEQRES records:

>d4iq6a_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
vttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknr
elqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpvi
yvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsy
icsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtp
treqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleaca
hsffdelrdpnvklpngrdtpalfnfttqelssnpplatilippha

Sequence, based on observed residues (ATOM records):

>d4iq6a_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
vttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfknr
elqimrkldhcnivrlryffysylnlvldyvpetvyrvarhysrakqtlpviyvklymyq
lfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsryyra
pelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreqirem
npwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnvklpngrdtpa
lfnfttqelssnpplatilippha

Timeline for d4iq6a_:

• d4iq6a_ is new in SCOPe 2.04-stable
  
• d4iq6a_ appears in SCOPe 2.05
  
• d4iq6a_ appears in the current release, SCOPe 2.08