SCOPe 2.07: Domain d4id7a_: 4id7 A:

Lineage for d4id7a_ (4id7 A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111201] (10 PDB entries)
   Uniprot Q07912 117-389

8. Domain d4id7a_: 4id7 A: [252613]
   automated match to d1u54a_
   complexed with 1g0, so4

Details for d4id7a_

PDB Entry: 4id7, 3 Å

PDB Description: ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol

PDB Compounds: (A:) Activated CDC42 kinase 1

SCOPe Domain Sequences for d4id7a_:

Sequence, based on SEQRES records:

>d4id7a_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdvlsqpeamddfir
evnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqv
aegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfaw
capeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedc
pqdiynvmvqcwahkpedrptfvalrdflleaq

Sequence, based on observed residues (ATOM records):

>d4id7a_ d.144.1.7 (A:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkppeamddfirevnam
hsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqvaegmg
yleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawcapes
lktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiy
nvmvqcwahkpedrptfvalrdflleaq

Timeline for d4id7a_:

• d4id7a_ first appeared in SCOPe 2.04
  
• d4id7a_ appears in SCOPe 2.06
  
• d4id7a_ appears in the current release, SCOPe 2.08