SCOPe 2.04: Domain d4hmka_: 4hmk A:

Lineage for d4hmka_ (4hmk A:)

1. Root: SCOPe 2.04

2. Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (1 family)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (35 PDB entries)
   Uniprot O67854 5-513

8. Domain d4hmka_: 4hmk A: [252467]
   automated match to d2q6ha_
   complexed with bog, br, leu, na

Details for d4hmka_

PDB Entry: 4hmk, 3 Å

PDB Description: crystal structure of leut-e290s with bound br

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d4hmka_:

Sequence, based on SEQRES records:

>d4hmka_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
krehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiew
amgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikfl
vglvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsil
irgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgv
wiaavgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekasvilggsisipaav
affgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpm
iafledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliif
fwifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtv
witrfyiiglflfltflvflaerrrnhes

Sequence, based on observed residues (ATOM records):

>d4hmka_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
krehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiew
amgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikfl
vglvpepptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirg
iskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwia
avgqifftlslgfgaiityasyvrkdqdivlsgltaatlnekasvilggsisipaavaff
gvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiaf
ledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwi
fgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyeethwtvwitrfyii
glflfltflvflaerrrnhes

Timeline for d4hmka_:

• d4hmka_ is new in SCOPe 2.04-stable
  
• d4hmka_ appears in SCOPe 2.05
  
• d4hmka_ appears in the current release, SCOPe 2.08