SCOPe 2.04: Domain d4h34a3: 4h34 A:219-537

Lineage for d4h34a3 (4h34 A:219-537)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein automated matches [190252] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187034] (21 PDB entries)

8. Domain d4h34a3: 4h34 A:219-537 [252372]
   Other proteins in same PDB: d4h34a1, d4h34a2
   automated match to d2shpa1
   complexed with edo, gol; mutant

Details for d4h34a3

PDB Entry: 4h34, 2.7 Å

PDB Description: crystal structure of the tyrosine phosphatase shp-2 with q506p mutation

PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4h34a3:

Sequence, based on SEQRES records:

>d4h34a3 c.45.1.2 (A:219-537) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvpteaqyrfiymav
qhyietlqrrieeeqkskr

Sequence, based on observed residues (ATOM records):

>d4h34a3 c.45.1.2 (A:219-537) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhsdyinaniimpefksyiatqgclqntvndfwrmvfqensrvivmttkevgkskcv
kywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgv
psdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdi
dvpktiqmvrsqrsgmvpteaqyrfiymavqhyietlqrrieeeqkskr

Timeline for d4h34a3:

• d4h34a3 is new in SCOPe 2.04-stable
  
• d4h34a3 appears in SCOPe 2.05
  
• d4h34a3 appears in the current release, SCOPe 2.08