Lineage for d4h34a3 (4h34 A:219-537)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2116263Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 2116264Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 2116365Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 protein domains)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4
  6. 2116561Protein automated matches [190252] (3 species)
    not a true protein
  7. 2116562Species Human (Homo sapiens) [TaxId:9606] [187034] (27 PDB entries)
  8. 2116589Domain d4h34a3: 4h34 A:219-537 [252372]
    Other proteins in same PDB: d4h34a1, d4h34a2
    automated match to d2shpa1
    complexed with edo, gol; mutant

Details for d4h34a3

PDB Entry: 4h34 (more details), 2.7 Å

PDB Description: crystal structure of the tyrosine phosphatase shp-2 with q506p mutation
PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4h34a3:

Sequence, based on SEQRES records: (download)

>d4h34a3 c.45.1.2 (A:219-537) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvpteaqyrfiymav
qhyietlqrrieeeqkskr

Sequence, based on observed residues (ATOM records): (download)

>d4h34a3 c.45.1.2 (A:219-537) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhsdyinaniimpefksyiatqgclqntvndfwrmvfqensrvivmttkevgkskcv
kywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgv
psdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdi
dvpktiqmvrsqrsgmvpteaqyrfiymavqhyietlqrrieeeqkskr

SCOPe Domain Coordinates for d4h34a3:

Click to download the PDB-style file with coordinates for d4h34a3.
(The format of our PDB-style files is described here.)

Timeline for d4h34a3: