SCOPe 2.08: Domain d4gkac_: 4gka C:

Lineage for d4gkac_ (4gka C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.2: Purine and uridine phosphorylases [53167] (2 families)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8

5. Family c.56.2.1: Purine and uridine phosphorylases [53168] (7 proteins)

6. Protein automated matches [190142] (21 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [256021] (7 PDB entries)

8. Domain d4gkac_: 4gka C: [252221]
   automated match to d1ulba_
   complexed with gol, po4; mutant

Details for d4gkac_

PDB Entry: 4gka, 2.2 Å

PDB Description: crystal structure of purine nucleoside phosphorylase (w16y, w94y, w178y, h257w) mutant from human complexed with phosphate

PDB Compounds: (C:) purine nucleoside phosphorylase

SCOPe Domain Sequences for d4gkac_:

Sequence, based on SEQRES records:

>d4gkac_ c.56.2.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gytyedykntaeyllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstvpg
hagrlvfgflngracvmmqgrfhmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpk
fevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstykqmge
qrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfslitn
kvimdyeslekanweevlaagkqaaqkleqfvsilmasiplp

Sequence, based on observed residues (ATOM records):

>d4gkac_ c.56.2.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gytyedykntaeyllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstvpg
hagrlvfgflngracvmmqgrfhmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpk
fevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstykqmge
qrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfslitn
kvimdyqaaqkleqfvsilmasiplp

Timeline for d4gkac_:

• d4gkac_ first appeared in SCOPe 2.04
  
• d4gkac_ appears in SCOPe 2.07