SCOPe 2.06: Domain d4fy0a_: 4fy0 A:

Lineage for d4fy0a_ (4fy0 A:)

1. Root: SCOPe 2.06

2. Class f: Membrane and cell surface proteins and peptides [56835] (59 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (1 family)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (38 PDB entries)
   Uniprot O67854 5-513

8. Domain d4fy0a_: 4fy0 A: [252093]
   automated match to d2q6ha_
   complexed with mse, na

Details for d4fy0a_

PDB Entry: 4fy0, 3 Å

PDB Description: Crystal structure of LeuT-F253A bound to L-selenomethionine from lipid bicelles

PDB Compounds: (A:) Transporter

SCOPe Domain Sequences for d4fy0a_:

Sequence, based on SEQRES records:

>d4fy0a_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
iaavgqifatlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaava
ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmi
afledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiff
wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvw
itrfyiiglflfltflvflaerrrn

Sequence, based on observed residues (ATOM records):

>d4fy0a_ f.54.1.1 (A:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagnavglgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirgi
skgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwiaa
vgqifatlslgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaffg
vanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiaimqpmiafl
edelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwif
gadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwitr
fyiiglflfltflvflaerrrn

Timeline for d4fy0a_:

• d4fy0a_ first appeared in SCOPe 2.04
  
• d4fy0a_ appears in SCOPe 2.05
  
• d4fy0a_ appears in SCOPe 2.07
  
• d4fy0a_ appears in the current release, SCOPe 2.08