SCOPe 2.07: Domain d4flha1: 4flh A:145-321

Lineage for d4flha1 (4flh A:145-321)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d4flha1: 4flh A:145-321 [252033]
   Other proteins in same PDB: d4flha2, d4flha3, d4flha4
   automated match to d1e7ua3
   complexed with 14k, so4

Details for d4flha1

PDB Entry: 4flh, 2.6 Å

PDB Description: crystal structure of human pi3k-gamma in complex with amg511

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4flha1:

Sequence, based on SEQRES records:

>d4flha1 d.15.1.5 (A:145-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipes
qseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d4flha1 d.15.1.5 (A:145-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftdfvlrvcgrdeylv
getpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d4flha1:

• d4flha1 first appeared in SCOPe 2.04
  
• d4flha1 appears in SCOPe 2.06
  
• d4flha1 appears in the current release, SCOPe 2.08