SCOPe 2.04: Domain d4fc0b_: 4fc0 B:

Lineage for d4fc0b_ (4fc0 B:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (13 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (490 PDB entries)

8. Domain d4fc0b_: 4fc0 B: [251949]
   automated match to d4kspb_
   complexed with 0t2

Details for d4fc0b_

PDB Entry: 4fc0, 2.95 Å

PDB Description: Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor

PDB Compounds: (B:) Serine/threonine-protein kinase B-raf

SCOPe Domain Sequences for d4fc0b_:

Sequence, based on SEQRES records:

>d4fc0b_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirm
qdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpk
amkrlmaeclkkkrderplfpqilasiellars

Sequence, based on observed residues (ATOM records):

>d4fc0b_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvksrwgsilwmapevirmqdknpysfqs
dvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaecl
kkkrderplfpqilasiellars

Timeline for d4fc0b_:

• d4fc0b_ is new in SCOPe 2.04-stable
  
• d4fc0b_ appears in SCOPe 2.05
  
• d4fc0b_ appears in the current release, SCOPe 2.08