SCOPe 2.06: Domain d4ezla1: 4ezl A:144-320

Lineage for d4ezla1 (4ezl A:144-320)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (65 PDB entries)

8. Domain d4ezla1: 4ezl A:144-320 [251841]
   Other proteins in same PDB: d4ezla2, d4ezla3, d4ezla4, d4ezla5
   automated match to d1e7ua3
   complexed with 0se

Details for d4ezla1

PDB Entry: 4ezl, 2.94 Å

PDB Description: Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4ezla1:

Sequence, based on SEQRES records:

>d4ezla1 d.15.1.5 (A:144-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrk

Sequence, based on observed residues (ATOM records):

>d4ezla1 d.15.1.5 (A:144-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkeqdfvlrvcgrd
eylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrk

Timeline for d4ezla1:

• d4ezla1 first appeared in SCOPe 2.04
  
• d4ezla1 appears in SCOPe 2.05
  
• d4ezla1 appears in SCOPe 2.07
  
• d4ezla1 appears in the current release, SCOPe 2.08