SCOPe 2.04: Domain d4er5a_: 4er5 A:

Lineage for d4er5a_ (4er5 A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families)

5. Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)

6. Protein automated matches [191247] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189737] (16 PDB entries)

8. Domain d4er5a_: 4er5 A: [251800]
   automated match to d1nw3a_
   complexed with 0qk, unx

Details for d4er5a_

PDB Entry: 4er5, 2.57 Å

PDB Description: crystal structure of human dot1l in complex with 2 molecules of epz004777

PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d4er5a_:

Sequence, based on SEQRES records:

>d4er5a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpe
klnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhy
gvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnf
afgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsv
swtgkpvsyylhtidrtilenyfsslknpklreeqeaa

Sequence, based on observed residues (ATOM records):

>d4er5a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklameydtksfe
smqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpeklnnye
pfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekad
ipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpev
dhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvskpvsy
ylhtidrtilenyfsslknpklreeqeaa

Timeline for d4er5a_:

• d4er5a_ is new in SCOPe 2.04-stable
  
• d4er5a_ appears in SCOPe 2.05
  
• d4er5a_ appears in the current release, SCOPe 2.08