Lineage for d4ekga_ (4ekg A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2129295Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 2129296Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families) (S)
  5. 2130146Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 protein domains)
  6. 2130154Protein automated matches [191247] (1 species)
    not a true protein
  7. 2130155Species Human (Homo sapiens) [TaxId:9606] [189737] (27 PDB entries)
  8. 2130168Domain d4ekga_: 4ekg A: [251771]
    automated match to d1nw3a_
    complexed with 0qj

Details for d4ekga_

PDB Entry: 4ekg (more details), 2.8 Å

PDB Description: Crystal Structure of DOT1L in Complex with EPZ003696
PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d4ekga_:

Sequence, based on SEQRES records: (download)

>d4ekga_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslkn

Sequence, based on observed residues (ATOM records): (download)

>d4ekga_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenydydtks
fesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpeklns
pevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipa
kyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhq
lkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvswtgkpvsy
ylhtidrtilenyfsslkn

SCOPe Domain Coordinates for d4ekga_:

Click to download the PDB-style file with coordinates for d4ekga_.
(The format of our PDB-style files is described here.)

Timeline for d4ekga_: