Lineage for d4ek9a_ (4ek9 A:)

  1. Root: SCOPe 2.05
  2. 1815291Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1864482Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
    core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
  4. 1864483Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families) (S)
  5. 1865322Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)
  6. 1865330Protein automated matches [191247] (1 species)
    not a true protein
  7. 1865331Species Human (Homo sapiens) [TaxId:9606] [189737] (16 PDB entries)
  8. 1865342Domain d4ek9a_: 4ek9 A: [251770]
    automated match to d1nw3a_
    complexed with ep4, gol, so4

Details for d4ek9a_

PDB Entry: 4ek9 (more details), 2.5 Å

PDB Description: Crystal structure of DOT1L in complex with EPZ000004
PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d4ek9a_:

Sequence, based on SEQRES records: (download)

>d4ek9a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslknp

Sequence, based on observed residues (ATOM records): (download)

>d4ek9a_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenydydtks
fesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpeklnn
yepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvek
adipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgp
evdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvswtg
kpvsyylhtidrtilenyfsslknp

SCOPe Domain Coordinates for d4ek9a_:

Click to download the PDB-style file with coordinates for d4ek9a_.
(The format of our PDB-style files is described here.)

Timeline for d4ek9a_: