SCOPe 2.06: Domain d4eb8c_: 4eb8 C:

Lineage for d4eb8c_ (4eb8 C:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.2: Purine and uridine phosphorylases [53167] (2 families)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8

5. Family c.56.2.1: Purine and uridine phosphorylases [53168] (7 proteins)

6. Protein automated matches [190142] (19 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [256021] (7 PDB entries)

8. Domain d4eb8c_: 4eb8 C: [251721]
   Other proteins in same PDB: d4eb8a2, d4eb8b2
   automated match to d1ulba_
   complexed with edo, im5, po4; mutant

Details for d4eb8c_

PDB Entry: 4eb8, 2.3 Å

PDB Description: Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate

PDB Compounds: (C:) purine nucleoside phosphorylase

SCOPe Domain Sequences for d4eb8c_:

Sequence; same for both SEQRES and ATOM records:

>d4eb8c_ c.56.2.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gytyedykntaeyllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstvpg
hagrlvfgflngracvmmqgrfhmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpk
fevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstykqmge
qrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfslitn
kvimdyeslekanweevlaagkqaaqkleqfvsilmasiplpd

Timeline for d4eb8c_:

• d4eb8c_ first appeared in SCOPe 2.04
  
• d4eb8c_ appears in SCOPe 2.05
  
• d4eb8c_ appears in SCOPe 2.07
  
• d4eb8c_ appears in the current release, SCOPe 2.08